Special Issues

 

The CiiEM is responsible through some of its Members, for the edition of one Special Collection, two Topical Collections and fourteen Special Numbers integrated in the indexed international journals, SAGE Journals, Diagnostics (ISSN 2075-4418), Biosensors (ISSN 2079-6374), International Journal of Environmental Research and Public Health (ISSN 1660-4601), Healthcare (ISSN 2227-9032), Applied Sicences (ISSN 2076-3417), Pharmaceutics (ISSN 1999-4923), International Journal of Environmental Research and Public Health (ISSN 1660-4601), Microorganisms (ISSN 2076-2607), Journal of Personalized Medicine (ISSN 2075-4426), Behavioral Sciences (ISSN 2076-328X) and Antioxidants (ISSN 2076-3921) from MDPI (Multidisciplinary Digital Publishing Institute) and four Research Topic integrated in the indexed international journal Frontiers in Molecular Biosciences, Frontiers in Bioengineering and Biotechnology, Frontiers in Nutrition and Frontiers in Human Neuroscience - Brain Health and Clinical Neuroscience.

 

NEW:

 

Research Topic "Personalized Care in Neurological Diseases"

(Frontiers in Human Neuroscience - Brain Health and Clinical Neuroscience)

 

Personalized Care in Neurological Diseases | Frontiers Research Topic (frontiersin.org) 

 

Guest Editors:

Prof. Dr. Catarina Godinho

Prof Dr. Júlio Fernandes

 

Living with a neurological disease can be stressful because it changes patients' lives, distressing their physical or/and mental health or threatening their survival. Nevertheless, people are able to take steps to cope with these new situations, manage their condition, and maintain a good quality of life. These patients have different disease statuses and management requirements, so providing personalized care is key. Personalized care is a collaborative process that should be used in chronic condition management in which patients, caregivers, and healthcare providers identify and discuss problems caused by or related to the patient's condition and then develop plans and goals to empower patients.

Personalized care can improve aspects of physical health, mental health, and the ability to self-manage conditions. Thus, a personalized care approach could greatly benefit patients with neurological diseases. It represents an opportunity to improve care for all individuals from a singular or collective point of view that holds promise for the prevention and treatment of diseases.

There have been developments in studies related to delivering personalized care for people with neurological diseases. In addition, current research expanding on the optimization of treatment outcomes in terms of efficacy, safety, and quality of life is encouraging.
In this Research Topic, we aim to publish articles describing a personalized care approach to diagnosing and treating patients with neurological diseases.

  

 

PREVIOUS:

 

Special Issue "Technique and Diagnose of Viruses in Electron Microscopy"

(microorganisms)

 

Microorganisms | Special Issue : Technique and Diagnose of Viruses in Electron Microscopy (mdpi.com)

 

Guest Editor: 

Prof. Dr. António P. Alves de Matos

 

Electron microscopy is an essential method for visualization of virus particles and virus-cell interactions. Due to the distinctive ultrastructure of virus particles, the technique has a key role in the identification of viruses in infected tissues up to the family level, with direct implications for new virus discovery and diagnosis. This volume presents the scientific and technological knowledge needed to understand the diagnostic rationale and procedures and to successfully implement the transmission electron microscopy (TEM) methods for virus identification.

Dedicated chapters by experienced microscopists will address virus ultrastructural characteristics at the family level, practical issues of virus morphological identification, negative staining and thin section methods, and their diagnosis-related variations.

Quick identification of unknown pathogens, differentiation between viruses producing skin lesions and other viruses, and other significant diagnostic contributions of TEM will be discussed in comprehensive chapters. This will empower researchers and clinicians to take advantage of the methods presented.

Future perspectives of the field will be treated in depth.

 

 

Research Topic "Digital Approaches in the Nutitional Prevention and Management of Chronic Diseases"

 

(Frontiers in Nutrition)

 

Digital Approaches in the Nutritional Prevention and Management of Chronic Diseases | Frontiers Research Topic (frontiersin.org)

 

Guest Editors:

Prof. Dr. Mara Pereira Guerreiro

Prof Dr. José Camolas

 

Chronic diseases are a global epidemic, responsible for the majority of deaths worldwide. Cardiovascular disease, cancer, diabetes, and chronic lung diseases present the highest prevalence, which is projected to increase in the next decades across the globe. In addition to morbidity and mortality, chronic diseases are associated with a considerable economic burden for governments and individuals, as well as losses for economies.


Addressing the burden of chronic diseases is enshrined in the United Nations’ Sustainable Development Goals, in particular, “Good health and well-being”, and subsumed targets and indicators.

Diet and nutrition are major modifiable determinants of chronic diseases, both at prevention (e.g. type 2 diabetes) and management levels (e.g. obesity).

Addressing diet and nutrition in chronic diseases requires trained health professionals and continued support. The sustainability of quality nutrition care in many countries is threatened by a constellation of factors, such as population ageing, the rising burden of chronic diseases and a shortage of health professionals. These factors have driven the reengineering of care processes.

Globally, there is strong policy support for the meaningful use of digital health innovations for citizen empowerment. Specifically, digital technology became popular for expediting the nutrition care process and enhancing dietary self-management. There is a growing body of evidence on the benefits of digital technology in nutritional outcomes in persons with or at risk for chronic disease.

The goal of this research topic is to present a state-of-the-art collection of approaches in nutritional prevention and management of chronic diseases, which is expected to foster advances in practice and research whilst minimizing wasteful redundancies.
 

 

Special Issue "The Importance of Thioredoxin System for Redox Regulation and Health"

(Antioxidants)

Antioxidants | Special Issue : The Importance of Thioredoxin System for Redox Regulation and Health (mdpi.com)

 

Guest Editor: 

Prof. Dr. Vasco Branco

 

Thioredoxin system encompasses thioredoxin reductase (TrxR), thioredoxin (Trx) and NADPH and is central to the regulation of cell redox homeostasis. Trx was discovered 60 years ago as a hydrogen donor for the reduction of ribonucleotides by ribonucleotide reductase (RNR) and is fundamental for repairing oxidized proteins.

TrxR isoforms, TrxR1; TrxR2; TrxR3 also known as TGR, besides their importance to regenerate oxidized thioredoxin in cytoplasm and in mitochondria, have been decisive to understand the importance of selenium as a micronutrient and its risk–benefit relationship as an antioxidant. Toxification processes have been linked to TrxR inhibition at the active site Sec by xenobiotics such as heavy metals.

The importance of the thioredoxin system extends far beyond the direct action of Trx, TrxR and NADPH as antioxidants. There are crucial interactions of these elements that become determinant for Redox Biology. Examples of those are the complexes between Trx and Apoptosis Signaling Kinase 1 (ASK-1) or Thioredoxin interacting protein (TxniP); oxidation of Trx, as a result of oxidative stress, releases ASK-1 and triggers an apoptotic cascade.

The thioredoxin system is of outmost importance for protein repair and folding, oxidative stress defense, redox signaling, DNA replication and repair, transcription; glucose metabolism, cell cycle arrest and apoptosis regulation. Dysregulation and disrepair of the thioredoxin system has been related to pathological processes such as inflammation, cancer, neurodegenerative and cardiovascular diseases, and diabetes, among others.

 

 

Specil Issue "Reading, Writing, and Arithmetic: Typical and Atypical Cognitive Development"

(Behavioral Development)

Behavioral Sciences | Special Issue : Reading, Writing, and Arithmetic: Typical and Atypical Cognitive Development (mdpi.com)

 

Guest Editor:

Prof. Dr. Luís Querido

 

The goal of this Special Issue is to increase our understanding of how children acquire the proverbial three Rs: reading, writing, and arithmetic. Several cognitive skills such as phonological awareness, orthographic knowledge, and rapid automatized naming have been recognized as fundamental for reading and writing development. Likewise, number sense and counting have been pointed out as crucial for the development of arithmetic skills. Recent research has even suggested a considerable overlap in the cognitive predictors of reading, writing, and/or arithmetic skills. Clarifying cross- and within-domain predictors is important since they may carry significant implications for cognitive developmental theories and practice. Within this scope, we welcome contributions from research groups worldwide, focusing on typical and/or atypical acquisition of reading, writing, and arithmetic skills.

We intend to select new empirical research and studies that use a systematic framework that has not been published elsewhere. Research issues may be addressed employing quantitative methodologies or provide a systematic review on a topic of the three Rs.

  

Specil Issue "Insigths into Hygiene, Disinfection Measures and Preventive Actions"

(International Journal of Environmental Research and Public Health)

IJERPH | Special Issue : Insights into Hygiene, Disinfection Measures and Preventive Actions (mdpi.com)

 

Guest Editor: 

Prof. Dr. Helena Barroso

 

The lack of hygiene has always been associated with infections, sometimes of catastrophic proportions. In the 19th century, Semmelweis, with the introduction of a simple gesture of washing and disinfecting doctors’ hands, greatly reduced the deaths of parturients. Today, washing and disinfecting hands is still fundamental for controlling the spread of infections, as can be observed during the present SARS-CoV-2 pandemic and in the light of the common infections occurring in the healthcare environment.

Disinfection and antisepsis are extremely important in controlling infections and reducing the transmission of pathogenic microorganisms, both in hospitals and in society. The disinfection of surfaces and environments is vital in the food and pharmaceutical industries as a means of guaranteeing the production of safe products. The development of measures that contribute to the prevention of infections is increasingly essential.

This Special Issue of International Journal of Environmental Research and Public Health (IJERPH) focuses mainly on hygiene and disinfection, along with all the different preventive measures that might be implemented to control the spread of infectious diseases and to guarantee a safe environment. Papers addressing these topics are invited for this Special Issue, to which manuscripts from different scientific areas will be welcomed.

 

Topical Collection "E-learning and Digital Training in Healthcare Education: Current Trends and New Challenges"

(Healthcare)

Healthcare | Topical Collection : E-learning and Digital Training in Healthcare Education: Current Trends and New Challenges (mdpi.com)

 

Guest Editors:

Prof. Dr. Luís Proença

Prof. Dr. José João Mendes

Prof. Dr. João Botelho

Prof. Dr. Vanessa Machado

   

The COVID-19 pandemic had a massive impact on the learning and teaching processes, especially in healthcare education, due to the predominant role of the current student–patient interaction. Worldwide higher education institutions were forced to accelerate the introduction of web-based learning methodologies in areas where that was not the main core, like clinical teaching. This Special Issue is dedicated to the current trends and new challenges that emerge from this new e-learning environment, focusing on its potential to revolutionize healthcare education and exploring how it may help to better prepare the future healthcare professionals for their daily practice.

The Special Issue “E-learning and Digital Training in Healthcare Education: Current Trends and New Challenges” seeks research articles focusing on new insights into the use of interactive and intuitive e-learning tools and innovative teaching methodologies that engage healthcare students in the new web-based environment training. Case studies of ‘pathfinder’ e-learning initiatives and surveys related to the penetration and acceptance of the digital training in healthcare education are also encouraged.

 

Special Collection on the Therapeutic Progression in Inflammatory Periodontal and Peri-Implant Disease

(Therapeutic Advances in Chronic Disease)

Special Collection on the Therapeutic Progression in Inflammatory Periodontal and Peri-Implant Disease: Therapeutic Advances in Chronic Disease: SAGE Journals (sagepub.com) 

Guest Editors:

Prof. Dr. João Botelho

Prof. Dr. Vanessa Machado

Prof. Dr. José João Mendes

 

Periodontal conditions, and recently peri-implant diseases, have been associated with systemic health. Several putative mechanisms are becoming evident that link these alveolar bone inflammatory disorders with systemic status, getting closer and closer to drug candidates or comprehensive treatments. This Special Collection aims to encourage researchers to present from observation to intervention trials, as well reviews and evidence-based studies. 

 

 

Specil Issue "Research on Antibiotic Resistance within one Health"

(International Journal of Environmental Research and Public Health)

Special Issue : Research on Antibiotic Resistance within One Health (mdpi.com)

Guest Editor: 

Prof. Dr. Lucinda J. Bessa

 

Antimicrobial resistance (AMR) is a complex, multifaceted problem that threatens human and animal health, the global economy, and national and global security. The World Health Organization (WHO) has included AMR as one of the top ten threats to global health in 2019. Thus, there is a need for a thorough One Health approach to address AMR that incorporates human, animal, and environmental perspectives and identifies key priorities for research. Research on antibiotic resistance is advancing in a variety of approaches and innovative strategies for tackling multidrug-resistant infections are looked-for. Some of the topics regarding research on antibiotic resistance include characterization of multidrug-resistant isolates from clinical and environmental sources, spread of resistance and antibiotic resistance genes in the environment, study of biofilms and antibiofilm strategies, antibiotic drug discovery, repurposing of existing drugs, innovative technologies for diagnostics or treatment, meta-analysis, and longitudinal studies. Papers addressing these topics are welcome in this Special Issue, especially those providing novel solutions to combat antibiotic resistance. Original research papers, reviews, case reports, methodological papers, and brief reports are invited.

 

Research Topic "Enzyme or Protein on Electrodes for Biosensors and Biofuel Cells"  

(Frontiers in Bioengineering and Biotechnology)

Enzyme or Protein on Electrodes for Biosensors and Biofuel Cells | Frontiers Research Topic (frontiersin.org)

Guest Editor:

Prof. Dr. Gabriela Almeida

 

Enzymes/proteins immobilized on electrodes can be used in applications such as biosensors and biofuel cells. Immobilizing enzymes or proteins on electrodes allows chemical reactions or electron transfers to occur at room temperature. However, the activity of enzymes/proteins on electrodes is limited by current intensity, suboptimal orientation, and mechanical stability. Advances in protein engineering and electrode surface modification technology, including methods to increase the lifetime of enzymes/proteins and their stability in actual scenario, have addressed these deficiencies. In particular, electrode materials and modification methodologies are highly significant for improving electron transfer between surfaces and enzymes/proteins; thus, the exploitation of novel immobilization strategies with improved efficiency is crucial and has attracted substantial attention in recent years.

 

 

Special Issue "Personalized Care and Treatment Compliance in Chronic Conditions"

(Journal of Personalized Medicine)

https://www.mdpi.com/journal/jpm/special_issues/treatment_compliance

Guest Editors:

Prof. Dr. Catarina Godinho

Prof. Dr. Júlio Belo Fernandes

 

Chronic diseases such as diabetes, cancer, cardiovascular and neurodegenerative diseases are growing at an alarming rate, especially in the aging population. People who have chronic disease spend a significant amount of time in self-management in out-of-hospital environments, in their homes and in their community settings. These patients have different disease statuses and management requirements, so providing personalized care is key.

We aim to publish articles describing a personalized care approach to the diagnosis and treatment to chronically ill patients.

Personalised care is a collaborative process that should be used in chronic condition management in which patients, caregivers and healthcare providers identify and discuss problems caused by or related to the patient's condition, and then develop plans and goals to empower patients. 

Personalized care can improve aspects of physical health, mental health and the ability to self-manage conditions. Thus, a personalized care approach could greatly benefit patients with chronic conditions.

We encourage the submission of manuscripts that describe a personalized care approach to the diagnosis and treatment to chronically ill patients.

 

 

Topical Collection "Diagnostic Virology"

(Diagnostics)

https://www.mdpi.com/journal/diagnostics/special_issues/diagnostic_virology

Collection Editor

Prof. Dr. Nuno Taveira

 

In these troubled COVID-19 times we are living in, it has become more evident than ever that rapid, deployable, and highly sensitive, specific and precise diagnostic assays can save many lives. Together with the established qPCR-based and isothermal amplification-based methods, new technologies such as those based on CRISPR-Cas13 system and metagenomics are emerging and are enabling the rapid and sensitive detection and identification of multiple viruses at the same time with an unprecedented quality, both in the lab and outside the lab (PoC assays). These molecular methods of diagnostics rely on nucleic acid extraction methods whose performance characteristics may be very diverse and need a better assessement. High quality serologic assays are also paramount for the diagnosis and management of virus diseases, and for monitoring the response to vaccination. A better understanding of the advantages and limitations of currently available molecular and serologic assays for the diagnosis, treatment management, and cure assessement of each virus disease is needed. There is no better time for this Special Issue in diagnostic virology. I would like to invite you to submit your best review or original work on all aspects of diagnostic virology mentioned above and others that I have missed to this topical collection issue. We are particularly seeking top level contributions on the development, validation, and implementation of molecular and serologic assays for the diagnosis, prognosis, and management of diseases caused by human viruses in all settings from the lab to the house and the bed of the patient.  

 

 

Special Issue "Virulence and Resistance of Klebsiella pneumoniae

(Microorganisms)

https://www.mdpi.com/journal/microorganisms/special_issues/virulence_resistance_Klebsiella

Guest Editor

Prof. Dr. Aida Duarte

  

Klebsiella pneumoniae is an important opportunistic Gram-negative pathogen that belongs to the Enterobacteriaceae family, which is frequently associated with severe healthcare-associated infections (HAI) as well as community-acquired infections. It can cause different types of infection such as pneumonia, urinary tract infection, skin or soft tissue infection, meningitis, pyogenic liver abscess, and bacteremia potentially developing into sepsis. It is believed that the gastrointestinal tract is the most important reservoir for the transmission of K. pneumoniae. However, in contrast to many other bacterial pathogens, K. pneumoniae is ubiquitous in nature, and environmental reservoirs can also have a relevant role in human infections. Infections resulting from multidrug-resistant (MDR), extended-spectrum beta-lactamase (ESBL), and/or carbapenemase-producing K. pneumoniae strains are a challenge due to the lack of vaccines and therapeutic options. Several virulence factors, such as adherence and invasion factors, toxins, capsules, and siderophores, can be involved in the pathogenic mechanisms, namely, invasion of the host, disease induction, and the evasion of host defenses. The coexistence of antimicrobial resistance genes with other advantageous determinants such as virulence factors can have a significant impact on bacterial pathogenicity. Moreover, recent population diversity studies have shown that K. pneumoniae is in fact part of a complex of species. The aim of this Special Issue is to give an updated insight into K. pneumonia-complex resistance and virulence determinants, and the interplay of these factors. For this purpose, we welcome the submission of research articles, review articles, and short communications related to the various aspects of K. pneumonia-complex infection, with particular emphasis on antimicrobial resistance, its transmissibility, molecular pathways, the coexistence of virulence factors, biomarkers, clinical and environmental reservoirs, high-risk clones, whole genome sequencing characterization, in vivo infection models, and bacterial pathogenicity.

 

   

Special Issue "New Techniques, Materials and Technologies in Dentistry"

(Applied Sciences)

 https://www.mdpi.com/journal/applsci/special_issues/dentistry_materials

Guest Editors

Prof. Dr. Ricardo Alves

Prof. Dr. José João Mendes

Prof. Dr. Ana Cristina Mano Azul

 

Dentistry has seen great technical and technological advances in recent years. These achievements have made it possible to increase the accuracy of the diagnosis, plan treatments more precisely, improve the predictability and durability of certain treatments, make procedures safer and faster, and improve the patient experience and acceptance, among others. The speed at which these advances are developing justifies the publication of a Special Issue that will allow clinicians to be aware of the latest breakthroughs in this field. Topics in this Special Issue include, but are not limited to, the following: new restorative materials, new regenerative materials, new surgical techniques, CAD-CAM systems, artificial intelligence in dentistry, robotics, and translational research. We encourage the submission of papers from different fields of dentistry and related areas. Original in vivo or in vitro studies that describe new therapeutic approaches or materials are strongly welcomed. Reviews on the aforementioned topics will also be considered for publication.

 

 

Special Issue "Minimizing the burden of Aging Disorders"

(International Journal of Environmental Research and Public Health)

(https://www.mdpi.com/journal/ijerph)

Guest Editor

Prof. Dr. Catarina Godinho

 

Assistant Guest Editor

Prof. Dr. Jorge Fonseca

 

The world is facing a situation without precedent: We soon will have more older people than children and more people at extreme old age than ever before (WHO, Global Health and Aging, 2011). In the last 100 years, populations in developed countries have experienced an unprecedented addition of 30 years to life expectancy. Developing countries are now experiencing this same phenomenon. With this comes the challenge of maximizing health and vitality across these aging population. The compression of morbidity to the latest point in the human life span could unleash a sustained third demographic dividend that benefits all of society (Fried LP, 2016). To accomplish this, society needs to invest in the prevention and treatment of chronic diseases, frailty and all the burden associated to the aging like falls prevention and cognitive impairment, for example. Papers addressing these topics are invited for this Special Issue, especially those combining a high academic standard coupled with a practical focus on providing input strategies to minimizing the burden of Aging.

This special issue of International Journal of Environmental Research and Public Health (IJERPH) focuses on the current state of knowledge on the how society in general and health professionals in particular can contribute to minimizing the burden of Aging Disorders. New research papers, reviews case reports and case series are welcome to this issue. Other manuscript types accepted include methodological papers, position papers and brief reports.

We will accept manuscripts from different disciplines including exposure assessment science, epidemiology, clinical studies, risk and health impact assessment and risk management.

 

 

Research Topic “Molecular Features Linking Amyloidogenic Toxicity and Antimicrobial Peptides”

(Frontiers in Molecular Biosciences)

(https://www.frontiersin.org/research-topics/17630/molecular-features-linking-amyloidogenic-toxicity-and-antimicrobial-peptides)

Guest Editor

Prof. Dr. Alexandre Quintas

 

This Research Topic aims do connect two fields of biochemistry and promote the interchange of knowledge between amyloid diseases and antimicrobial peptides.

 

 

Special Issue “Polymers enhancing bioavailability in drug delivery”

(Pharmaceutics)

https://www.mdpi.com/journal/pharmaceutics/special_issues/Polymers_Bioavailability_Drug_Delivery

Guest Editor

Prof. Dr. Ana Isabel Fernandes 

  

This Special Issue aims to review the specific functional benefits granted by polymers to formulations, which are very much reliant on polymer structure and design, and result in improved drug bioavailability and therapeutic index.

 

 

Special Issue "Novel Developments in the Bioproduction of Biochemicals and Biomaterials"

(Applied Sciences)

https://www.mdpi.com/journal/applsci/special_issues/Bioproduction_Biochemicals_Biomaterials

Guest Editor

Prof. Dr. Catarina Dias de Almeida

 

The Special Issue on Novel Developments in the Bioproduction of Biochemicals and Biomaterials in Applied Sciences intends to assemble recent advances and breakthroughs regarding the biological production of commercially important biomolecules. The wide scope of this issue is, however, limited to the production of biochemicals and biomaterials with nonfuel applications. Instead, processes that originate biochemical building blocks, biochemicals, biopolymers, and/or high end-value bioproducts for medical, pharmaceutical, cosmetics, and nutrition markets are preferred.

 

 

Special Issue "E-learning and Digital Training in Healthcare Education: Current Trends and New Challenges"

(Healthcare)

https://www.mdpi.com/journal/healthcare/special_issues/E-learning_Digital_Training_Healthcare_Education

Guest Editors

Prof. Dr. Luís Proença
Prof. Dr. José João Mendes
Dr. João Botelho
Dr. Vanessa Machado

 

The COVID-19 pandemic had a massive impact on the learning and teaching processes, especially in health education, due to the predominant role of student-patient interaction in that process. In view of this situation, Higher Education institutions around the world were forced to accelerate the introduction of online learning methodologies in areas where this was not the main focus, such as clinical teaching. This special issue is dedicated to current trends and new challenges that emerge from this new e-learning environment, highlighting its potential to revolutionize Health Education and exploring how it can help better prepare future Health professionals for their daily practice.

  

 

Special Issue "Periodontal Disease and Female Reproductive Health"

(International Journal of Environmental Research and Public Health)

https://www.mdpi.com/journal/ijerph/special_issues/Periodontal_Disease_Female_Reproductive_Health

Guest Editors

Prof. Dr. Maria Alexandra Bernardo
Dr. Vanessa Machado
Dr. João Botelho

 

The special issue “Periodontal Disease and Female Reproductive Health” is dedicated to scientific and clinical progress on the study of Periodontology in Women of childbearing age. In recent years, a body of scientific evidence has shown an association between periodontal disease and obstetric complications, however, the mechanism of this relationship is not yet fully understood. In addition, recent studies have revealed the potential impact of the subclinical inflammatory state produced by periodontitis on female infertility, which may act as a limiting, but modifiable, risk factor in conception. As contributions to this Special Number, interdisciplinary approaches are encouraged, as well as interventional studies, in addition to systematic reviews that explore the association mentioned above.

  

 

Special Issue "Biosensors for the Detection of Nitrogen-Based Compounds"

(Biosensors)

https://www.mdpi.com/journal/biosensors/special_issues/bios_Detec_nitrogen

Guest Editor

Prof. Dr. Maria Gabriela Almeida

 

Nitrogen is present in the environment in a wide variety of chemical compounds, such as nitrates, nitrites, nitric oxide, nitrous oxide, ammonia, hydroxylamine and also as organic nitrogen. The interconversion of these compounds, in the environment, constitutes the global biogeochemical cycle of nitrogen, which is unbalanced by the human supply of nitrogen compounds, in the soil, water and atmosphere. This represents a threat to Human Health and ecosystems, on a global scale, requiring strict control and monitoring of the most impacting nitrogen compounds, in accordance with national and international legislation. In addition, the search for effective nitrogen oxide analysis methodologies is also present in areas such as food quality control, biomedical research and clinical diagnosis.

 

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