Special Issues


The CiiEM is responsible through some of its Members, for the edition of one Topical Collection and nine Special Numbers integrated in the indexed international journals, Diagnostics (ISSN 2075-4418), Biosensors (ISSN 2079-6374), International Journal of Environmental Research and Public Health (ISSN 1660-4601), Healthcare (ISSN 2227-9032), Applied Sicences (ISSN 2076-3417), Pharmaceutics (ISSN 1999-4923), International Journal of Environmental Research, Public Health (ISSN 1660-4601), Microorganisms (ISSN 2076-2607), Journal of Personalized Medicine (ISSN 2075-4426) from MDPI (Multidisciplinary Digital Publishing Institute) and one Research Topic integrated in the indexed international journal Frontiers in Molecular Biosciences.




Special Issue "Personalized Care and Treatment Compliance in Chronic Conditions"

(Journal of Personalized Medicine)


Guest Editors:

Prof. Dr. Catarina Godinho

Prof. Dr. Júlio Belo Fernandes


Chronic diseases such as diabetes, cancer, cardiovascular and neurodegenerative diseases are growing at an alarming rate, especially in the aging population. People who have chronic disease spend a significant amount of time in self-management in out-of-hospital environments, in their homes and in their community settings. These patients have different disease statuses and management requirements, so providing personalized care is key.

We aim to publish articles describing a personalized care approach to the diagnosis and treatment to chronically ill patients.

Personalised care is a collaborative process that should be used in chronic condition management in which patients, caregivers and healthcare providers identify and discuss problems caused by or related to the patient's condition, and then develop plans and goals to empower patients. 

Personalized care can improve aspects of physical health, mental health and the ability to self-manage conditions. Thus, a personalized care approach could greatly benefit patients with chronic conditions.

We encourage the submission of manuscripts that describe a personalized care approach to the diagnosis and treatment to chronically ill patients.



Topical Collection "Diagnostic Virology"



Collection Editor

Prof. Dr. Nuno Taveira


In these troubled COVID-19 times we are living in, it has become more evident than ever that rapid, deployable, and highly sensitive, specific and precise diagnostic assays can save many lives. Together with the established qPCR-based and isothermal amplification-based methods, new technologies such as those based on CRISPR-Cas13 system and metagenomics are emerging and are enabling the rapid and sensitive detection and identification of multiple viruses at the same time with an unprecedented quality, both in the lab and outside the lab (PoC assays). These molecular methods of diagnostics rely on nucleic acid extraction methods whose performance characteristics may be very diverse and need a better assessement. High quality serologic assays are also paramount for the diagnosis and management of virus diseases, and for monitoring the response to vaccination. A better understanding of the advantages and limitations of currently available molecular and serologic assays for the diagnosis, treatment management, and cure assessement of each virus disease is needed. There is no better time for this Special Issue in diagnostic virology. I would like to invite you to submit your best review or original work on all aspects of diagnostic virology mentioned above and others that I have missed to this topical collection issue. We are particularly seeking top level contributions on the development, validation, and implementation of molecular and serologic assays for the diagnosis, prognosis, and management of diseases caused by human viruses in all settings from the lab to the house and the bed of the patient.  



Special Issue "Virulence and Resistance of Klebsiella pneumoniae



Guest Editor

Prof. Dr. Aida Duarte


Klebsiella pneumoniae is an important opportunistic Gram-negative pathogen that belongs to the Enterobacteriaceae family, which is frequently associated with severe healthcare-associated infections (HAI) as well as community-acquired infections. It can cause different types of infection such as pneumonia, urinary tract infection, skin or soft tissue infection, meningitis, pyogenic liver abscess, and bacteremia potentially developing into sepsis. It is believed that the gastrointestinal tract is the most important reservoir for the transmission of K. pneumoniae. However, in contrast to many other bacterial pathogens, K. pneumoniae is ubiquitous in nature, and environmental reservoirs can also have a relevant role in human infections. Infections resulting from multidrug-resistant (MDR), extended-spectrum beta-lactamase (ESBL), and/or carbapenemase-producing K. pneumoniae strains are a challenge due to the lack of vaccines and therapeutic options. Several virulence factors, such as adherence and invasion factors, toxins, capsules, and siderophores, can be involved in the pathogenic mechanisms, namely, invasion of the host, disease induction, and the evasion of host defenses. The coexistence of antimicrobial resistance genes with other advantageous determinants such as virulence factors can have a significant impact on bacterial pathogenicity. Moreover, recent population diversity studies have shown that K. pneumoniae is in fact part of a complex of species. The aim of this Special Issue is to give an updated insight into K. pneumonia-complex resistance and virulence determinants, and the interplay of these factors. For this purpose, we welcome the submission of research articles, review articles, and short communications related to the various aspects of K. pneumonia-complex infection, with particular emphasis on antimicrobial resistance, its transmissibility, molecular pathways, the coexistence of virulence factors, biomarkers, clinical and environmental reservoirs, high-risk clones, whole genome sequencing characterization, in vivo infection models, and bacterial pathogenicity.




Special Issue "New Techniques, Materials and Technologies in Dentistry"

(Applied Sciences)


Guest Editors

Prof. Dr. Ricardo Alves

Prof. Dr. José João Mendes

Prof. Dr. Ana Cristina Mano Azul


Dentistry has seen great technical and technological advances in recent years. These achievements have made it possible to increase the accuracy of the diagnosis, plan treatments more precisely, improve the predictability and durability of certain treatments, make procedures safer and faster, and improve the patient experience and acceptance, among others. The speed at which these advances are developing justifies the publication of a Special Issue that will allow clinicians to be aware of the latest breakthroughs in this field. Topics in this Special Issue include, but are not limited to, the following: new restorative materials, new regenerative materials, new surgical techniques, CAD-CAM systems, artificial intelligence in dentistry, robotics, and translational research. We encourage the submission of papers from different fields of dentistry and related areas. Original in vivo or in vitro studies that describe new therapeutic approaches or materials are strongly welcomed. Reviews on the aforementioned topics will also be considered for publication.



Special Issue "Minimizing the burden of Aging Disorders"

(International Journal of Environmental Research and Public Health)


Guest Editor

Prof. Dr. Catarina Godinho


Assistant Guest Editor

Prof. Dr. Jorge Fonseca


The world is facing a situation without precedent: We soon will have more older people than children and more people at extreme old age than ever before (WHO, Global Health and Aging, 2011). In the last 100 years, populations in developed countries have experienced an unprecedented addition of 30 years to life expectancy. Developing countries are now experiencing this same phenomenon. With this comes the challenge of maximizing health and vitality across these aging population. The compression of morbidity to the latest point in the human life span could unleash a sustained third demographic dividend that benefits all of society (Fried LP, 2016). To accomplish this, society needs to invest in the prevention and treatment of chronic diseases, frailty and all the burden associated to the aging like falls prevention and cognitive impairment, for example. Papers addressing these topics are invited for this Special Issue, especially those combining a high academic standard coupled with a practical focus on providing input strategies to minimizing the burden of Aging.

This special issue of International Journal of Environmental Research and Public Health (IJERPH) focuses on the current state of knowledge on the how society in general and health professionals in particular can contribute to minimizing the burden of Aging Disorders. New research papers, reviews case reports and case series are welcome to this issue. Other manuscript types accepted include methodological papers, position papers and brief reports.

We will accept manuscripts from different disciplines including exposure assessment science, epidemiology, clinical studies, risk and health impact assessment and risk management.



Research Topic “Molecular Features Linking Amyloidogenic Toxicity and Antimicrobial Peptides”

(Frontiers in Molecular Biosciences)


Guest Editor

Prof. Dr. Alexandre Quintas


This Research Topic aims do connect two fields of biochemistry and promote the interchange of knowledge between amyloid diseases and antimicrobial peptides.



Special Issue “Polymers enhancing bioavailability in drug delivery”



Guest Editor

Prof. Dr. Ana Isabel Fernandes 


This Special Issue aims to review the specific functional benefits granted by polymers to formulations, which are very much reliant on polymer structure and design, and result in improved drug bioavailability and therapeutic index.



Special Issue "Novel Developments in the Bioproduction of Biochemicals and Biomaterials"

(Applied Sciences)


Guest Editor

Prof. Dr. Catarina Dias de Almeida


The Special Issue on Novel Developments in the Bioproduction of Biochemicals and Biomaterials in Applied Sciences intends to assemble recent advances and breakthroughs regarding the biological production of commercially important biomolecules. The wide scope of this issue is, however, limited to the production of biochemicals and biomaterials with nonfuel applications. Instead, processes that originate biochemical building blocks, biochemicals, biopolymers, and/or high end-value bioproducts for medical, pharmaceutical, cosmetics, and nutrition markets are preferred.



Special Issue "E-learning and Digital Training in Healthcare Education: Current Trends and New Challenges"



Guest Editors

Prof. Dr. Luís Proença
Prof. Dr. José João Mendes
Dr. João Botelho
Dr. Vanessa Machado


The COVID-19 pandemic had a massive impact on the learning and teaching processes, especially in health education, due to the predominant role of student-patient interaction in that process. In view of this situation, Higher Education institutions around the world were forced to accelerate the introduction of online learning methodologies in areas where this was not the main focus, such as clinical teaching. This special issue is dedicated to current trends and new challenges that emerge from this new e-learning environment, highlighting its potential to revolutionize Health Education and exploring how it can help better prepare future Health professionals for their daily practice.



Special Issue "Periodontal Disease and Female Reproductive Health"

(International Journal of Environmental Research and Public Health)


Guest Editors

Prof. Dr. Maria Alexandra Bernardo
Dr. Vanessa Machado
Dr. João Botelho


The special issue “Periodontal Disease and Female Reproductive Health” is dedicated to scientific and clinical progress on the study of Periodontology in Women of childbearing age. In recent years, a body of scientific evidence has shown an association between periodontal disease and obstetric complications, however, the mechanism of this relationship is not yet fully understood. In addition, recent studies have revealed the potential impact of the subclinical inflammatory state produced by periodontitis on female infertility, which may act as a limiting, but modifiable, risk factor in conception. As contributions to this Special Number, interdisciplinary approaches are encouraged, as well as interventional studies, in addition to systematic reviews that explore the association mentioned above.



Special Issue "Biosensors for the Detection of Nitrogen-Based Compounds"



Guest Editor

Prof. Dr. Maria Gabriela Almeida


Nitrogen is present in the environment in a wide variety of chemical compounds, such as nitrates, nitrites, nitric oxide, nitrous oxide, ammonia, hydroxylamine and also as organic nitrogen. The interconversion of these compounds, in the environment, constitutes the global biogeochemical cycle of nitrogen, which is unbalanced by the human supply of nitrogen compounds, in the soil, water and atmosphere. This represents a threat to Human Health and ecosystems, on a global scale, requiring strict control and monitoring of the most impacting nitrogen compounds, in accordance with national and international legislation. In addition, the search for effective nitrogen oxide analysis methodologies is also present in areas such as food quality control, biomedical research and clinical diagnosis.


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