EDCTP

LIFE Study.

The LIFE Study is a cluster randomised cohort study conducted at public health maternities in Tanzania (Mbeya and Songwe Regions) and Mozambique (Sofala and Manica Provinces) evaluating the clinical impact of infant birth point-of-care test & treat procedures in HIV-infected neonates.

Principal Investigator in Portugal: Professor Doutor Nuno Taveira

Coordinator: Instituto Nacional de Saude (INS), Mozambique

Sponsor: Ludwig-Maximillians-Universität (LMU), Germany

Funder: European and Developing Countries Clinical Trials Partnership (EDCTP), UNITAID, Clinton Health Access Initiative (CHAI)

Anticipated impact:

Identification of novel strategies using PoC-VL and enhanced PNP to further reduce MTCT;

Demonstration that the UNAIDS 90:90:90 goals are achievable in infants by using PoC-EID linked to early ART and improved retention in care;

Impact of PoC-EID linked and nurse initiated early infant ART on long-term infant mortality/morbidity;

Cost effectiveness data on the impact of PoC-VL monitoring to reduce MTCT, and on the impact of PoCEID at birth and nurse initiated infant ART on long term HIV-infected infant health outcomes;

Enhanced understanding of the impact of early and very early ART on viral reservoirs and HIV remission in infants.

More information at: Life Study