The LIFE Study is a cluster randomised cohort study conducted at public health maternities in Tanzania (Mbeya and Songwe Regions) and Mozambique (Sofala and Manica Provinces) evaluating the clinical impact of infant birth point-of-care test & treat procedures in HIV-infected neonates.
Principal Investigator in Portugal: Professor Doutor Nuno Taveira
Coordinator: Instituto Nacional de Saude (INS), Mozambique
Sponsor: Ludwig-Maximillians-Universität (LMU), Germany
Funder: European and Developing Countries Clinical Trials Partnership (EDCTP), UNITAID, Clinton Health Access Initiative (CHAI)
Identification of novel strategies using PoC-VL and enhanced PNP to further reduce MTCT;
Demonstration that the UNAIDS 90:90:90 goals are achievable in infants by using PoC-EID linked to early ART and improved retention in care;
Impact of PoC-EID linked and nurse initiated early infant ART on long-term infant mortality/morbidity;
Cost effectiveness data on the impact of PoC-VL monitoring to reduce MTCT, and on the impact of PoCEID at birth and nurse initiated infant ART on long term HIV-infected infant health outcomes;
Enhanced understanding of the impact of early and very early ART on viral reservoirs and HIV remission in infants.
More information at: Life Study